I haven't done any of it yet, but there's plenty of room in the dash opening where the tweeters are mounted to pass speaker wire right past the stock tweeters.
Just carefully pop the tweeter grills off and take a look at the space around the tweeters in there. You'll see what I'm talking about.
2001 Lexus LS430
Pioneer DMH-2660NEX | Pioneer GM D1004 | Helix DSP.2 | Rockford Fosgate Power T400X4ad | Morel TiW 634Nd | Audison Prima AP1 | Dayton Audio Ultimax UM8-22
Again, just pop the grill and take a look instead of just guessing because yours is the ML and mine isn't.
2001 Lexus LS430
Pioneer DMH-2660NEX | Pioneer GM D1004 | Helix DSP.2 | Rockford Fosgate Power T400X4ad | Morel TiW 634Nd | Audison Prima AP1 | Dayton Audio Ultimax UM8-22